Steven T Kosak
Assistant Professor of Cell and Molecular Biology
Department of Cell & Molecular Biology
Northwestern University Feinberg School of Medicine
United States of America
Biography
My research group is keenly interested in untangling the relationship between the form and function of the human genome within the nucleus. To this end, we are developing methods and experimental strategies to analyze dynamic genomic reorganization in multiple models of cellular differentiation, including myogenesis, neurogenesis, and epidermal differentiation. We are specifically interested in inter- and intra-chromosomal associations as a function of lineage-restricted gene expression and linear gene arrangement. In addition, we are investigating: (1) gene polarity in nuclei within polarized cell types, (2) co-translational mRNA surveillance and protein quality control in the nucleus in models of neurodegeneration, (3) a role for homologous chromosome association in autoimmune disease, and (4) the role of a novel chromosome end structure in replicative aging and human progeroid syndromes.
Research Interest
Cell and Molecular Biology
Publications
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Persistent nuclear actin filaments inhibit transcription by RNA polymerase II Serebryannyy LA, Parilla M, Annibale P, Cruz CM, Laster K, Gratton E, Kudryashov D, Kosak ST, Gottardi CJ, de Lanerolle P Journal of Cell Science. 2016 Jan; 129(18): 3412-3425. doi:http://dx.doi.org/10.1242/jcs.195867. PMID: 27505898 PMCID: 27505898 ISSN: 0021-9533
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Topologically associated domains enriched for lineagespecific genes reveal expression-dependent nuclear topologies during myogenesis Neems DS, Garza-Gongora AG, Smith ED, Kosak ST Proceedings of the National Academy of Sciences of the United States of America. 2016 Mar 22; 113(12): E1691-E1700. doi:http://dx.doi.org/10.1073/pnas.1521826113. PMID: 26957603 PMCID: 26957603 ISSN: 0027-8424
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Coils spring into action: Cajal bodies and the genomic organization of transcription (comment DOI 10.1002/bies.201600144) Fanslow D, Kosak ST BioEssays. 2016 Dec; 38(12): 1190. doi:http://dx.doi.org/10.1002/bies.201600232. PMID: 27859481 ISSN: 0265-9247
