Francesca Elizabeth Duncan
Associate Professor
Department of Obstetrics and Gynecology
Northwestern University
United States of America
Biography
Research in the Duncan laboratory tests the overarching hypothesis that deterioration of gamete-intrinsic cellular pathways together with changes in the ovarian micoenvironment contribute to the reproductive age-associated decline in egg quantity and quality. Specifically her group uses mammalian model systems to investigate whether three mechanisms common to systemic aging underlie physiologic and iatrogenic reproductive aging: 1) genomic instability, 2) altered metabolism, and 3) fibrosis. These insights will help us design targeted interventions to ameliorate reproductive aging, laying the foundation to simultaneously improve women’s fertile-span and health-span across generations.
Research Interest
Obstetrics and Gynecology
Publications
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Khachatryan V, Erbacher R, Carrillo Montoya CA, Carvalho W, Górski M, Kotlinski D, Anderson J, Jez P, Ujvari B, Ozturk S, Lander R. Jet energy scale and resolution in the CMS experiment in pp collisions at 8 TeV. JINST. 2016 Jul 13;12(CERN-PH-EP-2015-305):P02014.
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Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016 Jan 2;12(1):1-222.
