Holly Van Remmen
Member and Program Chair
Aging & Metabolism Research Program
Oklahoma Medical Research Foundation
United States of America
Biography
B.S. Eastern Illinois University, Charleston, IL, 1983 Ph.D. University of Texas Health Science Center, San Antonio, TX, 1991 Postdoc UTHSC, San Antonio, TX, with Arlan Richardson, Ph.D., 1991-1995
Research Interest
Research program has focused on the role of oxidative stress and mitochondrial function in aging. We utilized a number of transgenic and knockout models with modified antioxidant defense systems to ask whether changes in antioxidant defense and oxidative stress modify lifespan as predicted by the long-standing Oxidative Stress Theory of Aging. In contrast to the predictions of this Theory, our studies have shown that modifying antioxidant defenses does not alter lifespan.
Publications
-
Masser DR, Clark NW, Van Remmen H, Freeman WM. Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle. Age (Dordr). 2016 Jul 21. [Epub ahead of print] [Abstract]
-
Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H. Sco2 deficient mice develop increased adiposity and insulin resistance. Mol Cell Endocrinol. 2017 Apr 18. pii: S0303-7207(17)30190-9. [Epub ahead of print] [Abstract]
-
Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N. Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health. Aging Cell. 2017 May 29. [Epub ahead of print]
