Rodger P. Mcever
Adjunct Professor
Biochemistry and Molecular Biology
Oklahoma Medical Research Foundation
United States of America
Biography
B.A., Yale University (cum laude), 1970 M.D., University of Chicago, 1974
Research Interest
During responses to infection and tissue injury, circulating leukocytes and platelets adhere to each other and to the endothelial surface of blood vessels. Dysregulated adhesion of these cells contributes to thrombotic and inflammatory disorders. Leukocytes first tether to and then roll on vascular surfaces, a prerequisite for the subsequent arrest and then migration of the cells into the underlying tissues.
Publications
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Mehta-D'souza P, Klopocki AG, Oganesyan V, Terzyan S, Mather T, Li Z, Panicker SR, Zhu C, McEver RP. Glycan Bound to the Selectin Low Affinity State Engages Glu-88 to Stabilize the High Affinity State under Force. J Biol Chem. 2017 Feb 10;292(6):2510-2518. [Abstract]
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Liu Z, Yago T, Zhang N, Panicker SR, Wang Y, Yao L, Mehta-D'souza P, Xia L, Zhu C, McEver RP. L-selectin mechanochemistry restricts neutrophil priming in vivo. Nat Commun. 2017 May 12;8:15196. [Abstract]
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Panicker SR, Mehta-D'souza P, Zhang N, Klopocki AG, Shao B, McEver RP. Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice. Blood. 2017 May 17. pii: blood-2017-02-770479. [Epub ahead of print] [Abstract]
