Xiao-hong Sun
Adjunct Professor
Microbiology
Oklahoma Medical Research Foundation
United States of America
Biography
Ph.D., Cornell University, Ithaca, New York, 1987
Research Interest
Hematopoiesis is a developmental process where hematopoietic stem cells differentiate into different cell types through a series of lineage decisions, which are largely orchestrated by precise transcriptional programs. The basic helix-loop-helix family of transcriptional regulators includes E proteins encoded by the E2A, HEB and E2-2 genes and their inhibitors called Id proteins (Id1-4). Id proteins dimerize with E proteins and inhibit the DNA binding activity of E proteins. Therefore, the net E protein activity in a cell is determined by the concentration of both E and Id proteins.
Publications
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* Zhao Y, Ling F, Griffin TM, He T, Towner R, Ruan H, Sun XH. Up-regulation of the Sirtuin 1 ( Sirt1) and peroxisome proliferator-activated receptor gamma coactivator-1alpha genes in white adipose tissue of Id1 deficient mice: implications in the protection against diet and age-induced glucose intolerance. J Biol Chem 289:29112-29122, 2014. [Abstract]
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Ling F, Kang B, Sun XH. Id Proteins: Small Molecules, Mighty Regulators. Curr Top Dev Biol 110C:189-216, 2014. [Abstract]
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Wang HC, Qian L, Zhao Y, Mengarelli J, Adrianto I, Montgomery CG, Urban JF Jr, Fung KM, Sun XH. Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus. J Immunol. 2017 Apr 15;198(8):3149-3156. Epub 2017 Mar 3. [Abstract]
