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Ilia Fishbein

Associate Professor
Pediatrics
Pennsylvania State University
United States of America

Biography

Dr. Ilia Fishbein is affiliated to Pediatrics, The University of Pennsylvania Health System. Dr. Ilia Fishbein is currently providing services as Associate Professor. Dr. Ilia Fishbein authored and co-authored multiple Recent advent of drug-eluting metal stents has significantly improved short-term and intermediate outcomes in patients undergoing coronary stenting. However, animal and clinical data shows that long-term efficacy of this new treatment is questionable. Most experts in the field agree that a presence of a stent per se perpetuate chronic foreign body response leading to eventual revascularization failure. To this end, attempts have been made to formulate stent fabricated from biodegradable polymers. Polyesters (e.g. polylactic acid; PLA) possess mechanical properties comparable to metals and thus represent uppermost interest. Fabrication of PLA stents is compatible with either bulk immobilization, or surface tethering of adenoviral vectors via cleavable cross-linker developed in our lab. Therapeutic gene constructs delivered from degradable stent platform might address excessive smooth muscle proliferation, migration and synthetic activity or/and accelerate stent decomposition..

Research Interest

Recent advent of drug-eluting metal stents has significantly improved short-term and intermediate outcomes in patients undergoing coronary stenting. However, animal and clinical data shows that long-term efficacy of this new treatment is questionable. Most experts in the field agree that a presence of a stent per se perpetuate chronic foreign body response leading to eventual revascularization failure. To this end, attempts have been made to formulate stent fabricated from biodegradable polymers. Polyesters (e.g. polylactic acid; PLA) possess mechanical properties comparable to metals and thus represent uppermost interest. Fabrication of PLA stents is compatible with either bulk immobilization, or surface tethering of adenoviral vectors via cleavable cross-linker developed in our lab. Therapeutic gene constructs delivered from degradable stent platform might address excessive smooth muscle proliferation, migration and synthetic activity or/and accelerate stent decomposition.

Publications

  • Fishbein I, Guerrero DT, Alferiev IS, Foster JB, Minutolo NG, et al. (2-17) Stent-based delivery of adeno-associated viral vectors with sustained vascular transduction and iNOS-mediated inhibition of in-stent restenosis. Gene Ther.

  • Battig Mark R, Fishbein Ilia, Levy Robert J, Alferiev Ivan S, Guerrero David, et al. (2017) Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system. Drug delivery and translational research.

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