Krzysztof Laudanski
Assistant Professor
Department of Anesthesiology and Critical Care MedicineÂ
Pennsylvania State University
United States of America
Biography
Dr. Krzysztof Laudanski is working as an Assistant Professor of Department of Anesthesiology & Critical Care at The University of Pennsylvania Health System. He received his MD (Medicine) from Warsaw Medical University, 1998. His research interests include: the outcome of the sepsis and pathomechanisms leading to short and long-term aberrancies of the immune system. More specifically, I focus on the development of the dendritic cells from monocytes during severe stress and development of T cell anergy. One of the leading hypothesize is that in some patients the development of naïve monocytes is skewed toward macrophages. This is leading to immunoparalysis due to the depletion of the dendritic cells pool. I am also interested in analyzing interaction between immune system components and neuronal system. In my research, he utilizes the animal and humanized models of sepsis as well as sampling of the population of patients.
Research Interest
the outcome of the sepsis and pathomechanisms leading to short and long-term aberrancies of the immune system. More specifically, I focus on the development of the dendritic cells from monocytes during severe stress and development of T cell anergy. One of the leading hypothesize is that in some patients the development of naïve monocytes is skewed toward macrophages. This is leading to immunoparalysis due to the depletion of the dendritic cells pool. I am also interested in analyzing interaction between immune system components and neuronal system. In my research, he utilizes the animal and humanized models of sepsis as well as sampling of the population of patients.
Publications
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Laudanski K, Ali H, Himmel A, Godula K, Stettmeier M, et al. (2009) The relationship between serum ferritin levels and electrocardiogram characteristics in acutely ill patients. Exp Clin Cardiol 14: 38-41
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Miller-Graziano CL, De A, Laudanski K, Herrmann T, Bandyopadhyay S, (2008) HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function. Novartis Found Symp 291: 196-208
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Laudanski K, De A, Miller-Graziano C, (2007) Exogenous heat shock protein 27 uniquely blocks differentiation of monocytes to dendritic cells. Eur J Immunol 37: 2812-2824