Dr. Lewis Chodosh, M.d., Ph.d.

Biography

Education B.S. (Molecular Biophysics & Biochemistry) Yale University, 1981 Ph.D. (Biochemistry) Massachusetts Institute of Technology, 1988 M.D.  Harvard Medical School, 1989

Research Interest

The Chodosh laboratory uses genetically engineered mouse models, patient samples and bioinformatics to understand the mechanisms by which cancers develop, progress to more aggressive states, and ultimately contribute to cancer mortality. A broad array of basic and translational research approaches are used to address problems of fundamental clinical importance to cancer patients by elucidating pathways and principles common to human cancers. These approaches encompass genetics, genomics, molecular biology, biochemistry, cell biology, computational biology, functional imaging, animal studies, preclinical trials and clinical investigation. Particular areas of interest include: pathways regulating cancer development, metastasis, tumor dormancy and recurrence; the use of genomics and computational approaches to understand genetic programs in cancer; the impact of obesity on cancer recurrence; the mechanisms by which pregnancy protects against breast cancer; and the use of non-invasive imaging approaches to study tumor biology.