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James R. Broach

Emeritus Professor
Molecular Biology
Princeton University
United States of America

Biography

Dr. Broach is Chair of the Department of Biochemistry and Molecular Biology at Penn State Hershey, Director of the Penn State Institute for Personalized Medicine and Professor Emeritus of Princeton University. He completed his undergraduate studies in Chemistry at Yale University in 1969 and his Ph.D. in Biochemistry from the University of California, Berkeley in 1973, where he also completed a Postdoctoral Fellowship in Medical Physics. Dr. Broach served on the Scientific Review Board of the Frederick Cancer Center of the National Cancer Institute and has served as a member of both the Genetics and the Genomics Study Sections and Chair of the Genomics, Computational Biology and Technology Study Section of the National Institutes of Health. He was Co-Founder and Director of Research for Cadus Pharmaceuticals and sits on the Board of Directors of Cadus Corporation. Dr. Broach was Professor of Molecular Biology at Princeton University from 1984-2012, where he served as Associate Director of the Lewis Sigler Institute for Integrative Genomics and Co-Director of the Center for Computational Biology. Dr. Broach is a Fellow of the American Academy of Microbiology and the Co-Director of the Life Sciences Research Foundation, a private organization that provides postdoctoral fellowships in the life sciences. Dr. Broach is a member of the Science Board of the Food and Drug Administration and served as Trustee of the University of Medicine and Dentistry of New Jersey and Commissioner on the New Jersey Commission on Cancer Research until 2012. He is a member of the executive committee of the Cancer Biology Training Consortium, a national organization promoting graduate and postdoctoral training in cancer biology. Dr. Broach has published more than 150 articles in the area of molecular biology and holds a number of patents in drug discovery technologies.

Research Interest

Biochemistry and Molecular Biology

Publications

  • Lippman SI, Broach JR., 2009, Protein kinase A and TORC1 activate genes for ribosomal biogenesis by inactivating repressors encoded by Dot6 and its homolog Tod6, J.Proc Natl Acad Sci 106, 19928-19933

  • Klosinska MM, Crutchfield CA, Bradley PH, Rabinowitz JD, Broach JR, 2011, Yeast cells can access distinct quiescent states, J.Genes Dev, 25, 336-349

  • Tolkunov D, Zawadzki KA, Singer C, Elfving N, Morozov AV, Broach JR, 2011, Chromatin remodelers clear nucleosomes from intrinsically unfavorable sites to establish nucleosome-depleted regions at promoters, J. Mol Biol Cell

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