Michael Levine
Professor
Molecular Biology
Princeton University
United States of America
Biography
Michael Levine's lab has studied mechanisms responsible for switching genes on and off in the early Drosophila embryo for over 30 years. These studies led to the characterization of the eve stripe 2 enhancer, short-range repression, and the regulation of long-range enhancer-promoter interactions. For nearly 20 years the Levine lab have also studied the gene networks underlying the development of a simple protovertebrate, the sea squirt Ciona intestinalis. These studies led to the identification of rudimentary tissues for key innovations of the vertebrate “new headâ€, including cranial neural crest, neurogenic placodes, and the second heart field. Dr. Michael Levine will begin his new post as Director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University in July 2015. He is currently Professor of Genetics at UC Berkeley (since 1996) and Chairman of the Chancellor’s Advisory Council for Biology since 2012. Dr. Levine was Head of the Division of Genetics, Genomics and Development from 2007-2011 and served as Acting Director of the Functional Genomics Program at the Joint Genome Institute (DOE) in 2001. Prior to that he held faculty positions at Columbia University and UCSD, and was a Visiting Professor of Zoology at the University of Zurich from 1999-2000.
Research Interest
Genetics and Genomics
Publications
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Bothma JP, Garcia HG, Ng S, Perry MW, Gregor T, Levine M., 2015, Enhancer additivity and non-additivity are determined by enhancer strength in the Drosophila embryo, J.Elife., 4
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Oktaba K, Zhang W, Lotz TSabrina, Jun DJayhyun, Lemke SBeatrice, Ng SPak, et al., 2015, ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system,J.Mol Cell., 57, 341-8
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Fukaya T, Lim B, Levine M., 2016, Enhancer Control of Transcriptional Bursting, J.Cell., 166, 358-68