Ulrike Dydak
Associate Professor of Health Sciences
Engneering
Purdue University
United States of America
Biography
After studying physics and mathematics at the University of Vienna, Austria, Dr. Dydak received her PhD and postdoctoral training in physics and engineering of Magnetic Resonance Imaging at the Swiss Federal Institute of Technology (ETH) Zürich, Switzerland. Dr. Dydak’s research is focused on the development of Magnetic Resonance Spectroscopy (MRS) techniques for the noninvasive in-vivo assessment of metabolite and neurotransmitter concentrations, and their application to study physiological and pathophysiological mechanisms. A long-term goal of this research is to translate these novel MRS methods into viable clinical diagnostic procedures that aid in disease detection as well as assessment of treatment response. Special emphasis of her work lies on the development of the in vivo detection and quantification of γ-aminobutyric acid (GABA), an inhibitory neurotransmitter, to study manganese-induced parkinsonian neurotoxicity and idiopathic Parkinson Disease. A second focus lies on the development of whole-liver phosphorous (31P) magnetic resonance spectroscopic imaging of the human liver to improve treatment monitoring in liver cancer
Research Interest
Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) Manganese Neurotoxicity Parkinson Disease GABA MRS and GABA mapping by MEGA spectroscopic imaging Fast spectroscopic imaging (MRSI) techniques Multi-nuclear MRSI (31P MRS) to monitor response to radiation treatment
Publications
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Xu, J, Dydak U, Harezlak J, Nixon J, Dzemidzic M, Gunn A.D., Karne H.S., Anand A (2013). Neurochemical Abnormalities in Unmedicated Bipolar Depression and Mania: a 2D 1H MRS Investigation. Psychiatry Res 30: 235-41.
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Long Z, Li XR, Xu J, Edden RA, Qin WP, Long LL, Murdoch JB, Zheng W, Jiang YM, Dydak U (2014). Thalamic GABA Predicts Fine Motor Performance in Manganese-Exposed Smelter Workers. PLoS One. 2014 Feb 4;9(2):e88220.
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Poole VN, Abbas K, Shenk TE, Breedlove EL, Breedlove KM, et al.(2014). MR Spectroscopic Evidence of Brain Injury in the Non-Diagnosed Collision Sport Athlete. Dev Neuropsychol 39: 459-73.
