chemistry and chemical biology
Rensselaer Polytechnic Institute
United States of America
Professor Wang applies nuclear magnetic resonance (NMR) spectroscopy to study Alzheimer's disease and Hedgehog signaling pathway.
Alzheimer's disease: amyloid production, aggregation and interaction, Hedgehog autopocessing: mechanism and relevance to cancer
Xie, J., Owen, T., Xia, K., Singh, A. V., Tou, E., Li, L., Arduini, B., Li, H., Wan, L. Q., Callahan, B., and Wang, C. (2015). Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation. J. Biol. Chem. 289(118): 11591-11600. Top 5 most viewed article March-April 2015 on JBC website.
Jian Xie, Timothy Owen, Ke Xia, Brian Callahan and Chunyu Wang (2016). A Single Aspartate Coordinates Two Catalytic Steps in Hedgehog Autoprocessing. Journal of the American Chemical Society. Article ASAP DOI: 10.1021/jacs.6b06928