Biomedical Sciences

Biomedical Sciences Experts

George I. Makhatadze

Constellation Chair
chemistry and chemical biology
Rensselaer Polytechnic Institute
United States of America


Dr. Makhatadze completed his postdoctoral work at the Department of Biology at the Johns Hopkins University before moving to his first faculty position in the Department of Chemistry and Biochemistry at Texas Tech University. After three years at Texas Tech he moved to the Penn State University College of Medicine, where he was Professor at the Department of Biochemistry and Molecular Biology and directed a graduate program in Chemical Biology. Dr. Makhatadze joined Rensselaer in 2007 as a Constellation Professor in Biocomputation and Bioinformatics. Dr. Makhatadze is on the editorial boards of the Journal of Biological Chemistry, Biochemica et Biophysica Acta, and Protein Engineering, Design and Selection. He is a member of the American Chemical Society, the American Society for Biochemistry and Molecular Biology, the Biophysical Society, the Federation of American Societies for Experimental Biology, and the Protein Society. He is also a past and present member of the scientific review committees for the National Institutes of Health (NIH) and the National Science Foundation (NSF).

Research Interest

bioinformatics, protein dynamics, protein folding


  • Chen C, Makhatadze GI (2017) Molecular Determinant of the Effects of Hydrostatic Pressure on Protein Folding Stability. Nature Communications 8:14561-14570.

  • Tzul FO, Vasilchuk D, Makhatadze GI (2017) Evidence for the Principle of Minimal Frustration in the Evolution of Protein Folding Landscapes. Proc Natl Acad Sci U S A. Feb 14. pii: 201613892. doi: 10.1073/pnas.1613892114.

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