chemistry and chemical biology
Rensselaer Polytechnic Institute
United States of America
Mark Wentland began his career in drug discovery in 1970 when he joined the medicinal chemistry department at Sterling Winthrop Inc. During his 24 years at Sterling Winthrop, he held various scientific and administrative leadership positions and was also Adjunct Professor of Chemistry at Rensselaer Polytechnic Institute where he taught over 30 graduate-level organic and medicinal chemistry courses. In 1994, he joined the chemistry faculty at Rensselaer as Professor of Chemistry. Following his retirement at the end of 2015, he was appointed to the position of Professor Emeritus. Since 1997, he holds the concurrent position of Adjunct Professor - Center for Neuropharmacology & Neuroscience at Albany Medical College.
Design and synthesis of novel therapeutics to treat human diseases
Wentland, M. P.; Lou, R.; Lu, Q.; Bu, Y.; Denhardt, C.; Jin, J.; Ganorkar, R.; VanAlstine, M. A.; Guo, C.; Cohen, D. J.; Bidlack, J. M. "Syntheses of novel high affinity ligands for opioid receptors" Bioorg. Med. Chem. Lett. 2009, 19, 2289–2294.
Conroy, J. L.; Fang, C.; Gu, J.; Zeitlin, S. O.; Yang, W.; Yang, J.; VanAlstine, M. A.; Nalwalk, J. W.; Albrecht, P. J.; Mazurkiewicz, J. E.; Snyder-Keller, A.; Shan, Z.; Zhang, S.; Wentland, M. P.; Behr, M.; Knapp, B. I.; Bidlack, J. M; Zuiderveld, O. P.; Leurs, R.; Ding, X.; Hough, L. B. "Opioids Activate Brain Analgesic Circuits Through Cytochrome P450/Epoxygenase Signaling." Nature Neuroscience, 2010, 13, 284-286.