Rosemary Elliott
Emeritus Professor
Department of Molecular and Cellular Biology
Roswell Park Cancer Institute
United States of America
Biography
Rosemary Elliott is an emeritus professor in the Department of Molecular and Cellular Biology at Roswell Park Cancer Institute. She has received BS (Chemistry) from Birmingham University, Birmingham, England, 1955, MS (Biochemistry) from State University of New York at Buffalo, 1962 and PhD (Biochemistry) from SUNYAB, Buffalo, NY, 1964. Her research interests include: Congenic Strains for Genes Affecting Colon Tumors. Our work involves a mouse model for susceptibility to carcinogen-induced colon cancer in mice. Strain ICR/Ha is highly sensitive to colon tumors using the carcinogen 1,2-dimethylhydrazine dihydrochloride (DMH) or its metabolite azoxymethane (AOM), while C57BL/6Ha is resistant. QTL analysis of a backcross involving these strains identified loci on Chrs 5, 12, 13, and 14 containing genes affecting the number of tumors produced after treatment. The goal is to identify the genes involved.
Research Interest
Congenic Strains for Genes Affecting Colon Tumors
Publications
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Blickwedehl J, McEvoy S, Wong I, Kousis P, Elliott R, et al. (2007) Proteasomes and proteasome activator 200 kDa (PA200) accumulate on chromatin in response to ionizing radiation. Radiation research 167: 663-674
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Purushothaman D, Elliott RW, Ruvinsky A, (2008) A search for transmission ratio distortions in offspring from crosses between inbred mice. Journal of genetics 87: 127-131
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Fujiwara K, Wie B, Elliott R, Nagase H, (2010) New outbred colony derived from Mus musculus castaneus to identify skin tumor susceptibility loci. Molecular carcinogenesis 49: 653-661
