Steven Pruitt

Biography

Dr. Steven Pruitt joined as Professor in the Department of Molecular and Cellular Biology at Roswell Park Cancer Institute. He has received BS (Biology) from George Mason University, Fairfax, VA and PhD (Biology) from University of Virginia, Charlottesville, VA. His research interest include: The overarching theme of work in this laboratory is to understand the mechanisms by which somatic stem cells maintain tissue homeostasis and the consequences of dysfunction in these mechanisms for age related disease. In particular, we are addressing fundamental issues concerning the relationship between cell proliferation, the role of errors in DNA replication on genetic damage accumulation, and the mechanisms by which cells and tissues manage this damage. Since somatic stem cells are critical for ongoing tissue maintenance and regeneration after injury in most tissues of vertebrates, this area of research intersects with a large number of basic biological processes and diseases of aging including cancer.

Research Interest

to understand the mechanisms by which somatic stem cells maintain tissue homeostasis and the consequences of dysfunction in these mechanisms for age related disease.