William Magner

Biography

Dr. William J. Magner joined the faculty of Roswell Park Cancer Institute in 1999 as a Research Scientist in the Department of Immunology, and was appointed Affiliate Member in 2000.Dr. Magner earned his doctoral degree in Biochemistry, with a minor in Immunology, from Case Western Reserve University, Cleveland, OH, in 1994. Between 1994 and 1999, he completed postdoctoral fellowship training at the National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD. Dr. Magner also is Instructor, Immunology Program, Roswell Park Graduate Division, University at Buffalo.Dr. Magner’s research interests, in collaboration with Dr. Tomasi, include the role of miRNA in regulating immune gene expression; the effect of histone acetylation on gene expression; effect of trichostatin A treatment on expression of genes of immunological interest in various tumors; use of targeted therapeutics which activate immune gene expression and enhance tumor immunogenicity; definition of the mechanisms of action of trichostatin A.Dr. Magner has authored or co-authored a number of journal publications and abstracts.

Research Interest

role of miRNA in regulating immune gene expression; the effect of histone acetylation on gene expression; effect of trichostatin A treatment on expression of genes of immunological interest in various tumors; use of targeted therapeutics which activate immune gene expression and enhance tumor immunogenicity; definition of the mechanisms of action of trichostatin A.