Animesh Barua
Associate Professor
Department of Cell & Molecular Medicine
Rush University
United States of America
Biography
Two main attributes characterize my research: the pursuit of excellence and seeking new experiences. In my childhood, I witnessed a friend’s mother die prematurely after suffering for approximately six months in excruciating pain. I found out later that she was suffering from a disease called cancer of the ovary for which neither an early detection test nor a curative drug is available. Later, I came to know that malnutrition, including lack of adequate protein, is a global cause of premature death. Thus, I was attracted to research and started studying genetics and breeding using chickens to improve breeds or strains of chickens for egg and protein production to increase protein supply. However, during my doctoral study, I serendipitously observed that a group of hens developed ovarian cancer. After a thorough search, published literature suggested that the case to death ratio due to ovarian cancer is very high. Moreover, the lack of a spontaneous animal model of ovarian cancer is a significant barrier to study the disease. Thus, I became interested to pursue my research career in ovarian cancer using the laying hen model of spontaneous ovarian cancer. For teaching, I believe that given a congenial and supportive environment and passionate teaching, students can develop knowledge that will serve them well as they progress to their future career path.
Research Interest
Research Areas are: Ovarian cancer: molecular pathogeneis, early detection and development of molecular targeted ultrasound imaging agents, immunotherapy development Uterine leiomyoma (fibroids): factors associated with fibroid development, prevention and its transformation to uterine cancer (leiomyosarcoma)
Publications
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Interleukin 16- (IL-16-) Targeted Ultrasound Imaging Agent Improves Detection of Ovarian Tumors in Laying Hens, a Preclinical Model of Spontaneous Ovarian Cancer. Barua A, Yellapa A, Bahr JM, Adur MK, Utterback CW, Bitterman P, Basu S, Sharma S, Abramowicz JS. Biomed Res Int. 2015;2015:567459. doi: 10.1155/2015/567459.
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Enhancement of Ovarian Tumor Detection by DR6-Targeted Ultrasound Imaging Agents in Laying Hen Model of Spontaneous Ovarian Cancer. Barua A, Edassery SL, McNeal S, Bahr JM, Bitterman P, Basu S, Sharma S, Abramowicz JS. Int J Gynecol Cancer. 2016 Oct;26(8):1375-85. doi: 10.1097/IGC.0000000000000784.
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Association of Immunosuppression with DR6 Expression during the Development and Progression of Spontaneous Ovarian Cancer in Laying Hen Model. McNeal S, Bitterman P, Bahr JM, Edassery SL, Abramowicz JS, Basu S, Barua A. J Immunol Res. 2016;2016:6729379. doi: 10.1155/2016/6729379.