Hiroshi Asahara
Professor
Molecular Medicine
Scripps Research Institute
United States of America
Biography
As a molecular biologist and orthopedic surgeon, Dr. Asahara's research focuses on examining the precise mechanism of chromatin-dependent gene regulation related to limb development. Combining these new findings in molecular and developmental biology, with clinical research in the field of locomotive science, our aim is to develop innovative new therapies that will benefit patients with arthritis, bone tumor and spinal cord injuries.
Research Interest
Molecular and Experimental Medicine
Publications
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Y. Kawakami, J. Rodriguez-Leon, C. M. Koth, D. Buscher, T. Itoh, A. Raya, J. K. Ng, C. Rodriguez Esteban, S. Takahashi, D. Henrique, M. F. Schwarz, H. Asahara, J. C. Belmonte. "MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb." Nat Cell Biol, 5(6) 513-9, 2003.
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T. Furumatsu, M. Tsuda, N. Taniguchi Y. Tajima, H. Asahara. "Smad3 induces chondrogenesis through the activation of SOX9 via CBP/p300 recruitment." J Biol Chem, 280(9), 8843-350, 2005.
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Y. Kawakami, M. Tsuda, S. Takahashi, N. Taniguchi, C.R. Esteban, M. Zemmyo,T. Furumatsu, M. Lotz, J.C. Belmonte, H. Asahara. "Transcriptional coactivator PGC-1a regulates chondrogenesis via association with Sox9." Proc Natl Acad Sci, USA, 102(7), 2414-9, 2005.
