Boyd Goodson
Professor
Chemistry
Southern Illinois University
United States of America
Biography
Postdoctoral Scholar, NSF Laboratory for Molecular Sciences at the California Institute of Technology
Research Interest
Current research interests of the Goodson Group: NMR and MRI enjoy wide applicability but suffer from poor detection sensitivity. For this reason, imaging and spectroscopy of low-concentration species—such as gases in lung spaces or metabolites in tissues—can be particularly challenging. To combat such problems, we are pursuing two “hyperpolarization” methods: (1) spin-exchange optical pumping (SEOP), a technique whereby high-power lasers are used to prepare hyperpolarized noble gases (primarily for enhanced biological imaging and spectroscopic applications); and (2) Signal Amplification by Reversible Exchange ("SABRE"), a chemical process where organometallic catalysts are used to transfer the high nuclear spin order of para-hydrogen to molecular agents for applications—including for ultimate use as metabolic MRI contrast agents to probe responses to treatment of various diseases.
Publications
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“Spin-Exchange Optical Pumping at High Xenon Densities and Laser Fluxes: Principles and Practice.†B.M. Goodson, N. Whiting, H. Newton, J.G. Skinner, K. Ranta, P. Nikolaou, M.J. Barlow, E.Y. Chekmenev, in: Hyperpolarized Xenon-129 Magnetic Resonance; T. Meersmann and E. Brunner, Eds., pp. 96-121 New Developments in NMR No. 4, RSC Publishing (2015).
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"NMR Signal Amplification by Reversible Exchange of Neat Liquids." R.V. Shchepin, M.L. Truong, T. Theis, A.M. Coffey, K.W. Waddell, F. Shi, W.S. Warren, B.M. Goodson, E.Y. Chekmenev, J. Phys. Chem. Lett., 6, 1961−1967 (2015).
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“Hyperpolarization Methods for MRS.†B.M. Goodson, N. Whiting, A.M. Coffey, P. Nikolaou, F. Shi, B.M. Gust, M.E. Gemeinhardt, R.V. Shchepin, J.G. Skinner, J.R. Birchall, M.J. Barlow, E.Y. Chekmenev, eMagRes; Vol 4: 797-810. DOI 10.1002/9780470034590.emrstm1457 (2015)
