Leonard Anderson
Assistant Professor
Physiology
Southern Illinois University
United States of America
Biography
Leonard Anderson is working as an assistant professor in the department of physiology at cardiovascular research institute. he completed his degree in Doctor of Philosophy in Molecular Genetics from Northwestern Medical School .
Research Interest
Vascular diseases involving hyperproliferation of VSMCs, such as atherosclerosis, is one of the major causes of mortality in the U.S. and one of the leading causes of mortality among African Americans. VSMCs play a critical role in early vasculogenesis and blood vessel maintenance. The requirement for VSMC replenishment after vessel injury by putative stem cell progenitors suggest unique changes in the cellular transcriptome when compared to other cell lineages such as neurons, skeletal muscle, and cardiomyocytes. Our lab is currently interested in defining the process by which pluripotent stem cells become VSMCs at the transcriptional and, hence, signal transduction level by utilizing various innovative genomics technologies (i.e. Agilent OligoArrays, Affymetrix GeneChips, and protein arrays) to identify novel genes and proteins that play a crucial role in early VSMC fate determination
Publications
-
Anderson LM, Choe SE, Yukhananov RY, Hopfner RL, Church GM, Pratt RE, Dzau VJ. Identification of a novel set of genes regulated by a unique liver X receptor-alpha -mediated transcription mechanism. J Biol Chem. 2003 Apr 25;278(17):15252-60. Epub 2003 Jan 27. PMID: 12551904
-
Morello F, de Boer RA, Steffensen KR, Gnecchi M, Chisholm JW, Boomsma F, Anderson LM, Lawn RM, Gustafsson JA, Lopez-Ilasaca M, Pratt RE, Dzau VJ. Liver X receptors alpha and beta regulate renin expression in vivo. J Clin Invest. 2005 Jul;115(7):1913-22. PMID: 16007255
-
Anderson LM, Gibbons GH. Notch: a mastermind of vascular morphogenesis. J Clin Invest. 2007 Feb;117(2):299-302. PMID: 17273550
