Bioinformatics & Systems Biology
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Swaine Chen

Senior Research Scientist
Developmental Biology
Staffordshire University
United States of America

Biography

2004 M.D., Ph.D. in Developmental Biology, Stanford University 1996 A.B. in Chemistry and Mathematics, Harvard University

Research Interest

I am taking an evolutionary approach to integrate high throughput sequencing technologies into the daily discovery process of microbiologists. To do this, I use a model of urinary tract infection (UTI) caused by Escherichia coli. The primary and most well-studied virulence factor enabling E. coli to cause UTI in the mammalian bladder is type 1 pili, a fibrous structure created by E. coli that allows them to bind to the bladder epithelium. Natural variations in the genes encoding type 1 pili exist and affect the ability of E. coli to cause disease.

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