Aaron D. Gitler
Professor
Department of Genetics
Stanford University School of Medicine
United States of America
Biography
Aaron D. Gitler is Professor of the Department of Genetics. His lab investigates the mechanisms of human neurodegenerative diseases.
Research Interest
We use the baker’s yeast, Saccharomyces cerevisiae, as a model system to study the cell biology underpinning protein-misfolding diseases like Parkinson's disease and ALS. Since dealing with misfolded proteins is an ancient problem, we hypothesize that the mechanisms employed to cope with them are likely conserved from yeast to man. Our long-term goal is to identify the critical genes and cellular pathways affected by misfolded human disease proteins.
Publications
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Jovicic A, Mertens J, Boeynaems S, Bogaert E, Chai N, et al. (2015) Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. Nature neuroscience 18(9): 1226-1229.
