Department of Genetics
Stanford University School of Medicine
United States of America
Laura Attardi is Professor Of Radiation Oncology (Radiation Biology) and Of Genetics.
Defining the transcriptional networks responsible for tumor suppression, using CRISPR/Cas9 and shRNA high-throughput genetic screening approaches, Identifying p53-interacting partners by mass spectrometry approaches, Elucidating the genes activated and repressed by p53 in diverse settings using genomic technologies such as ChIP-sequencing and RNA-sequencing, to understand how p53 drives different responses, Identifying p53 inhibitors to find strategies to suppress the detrimental effects of p53 activation, such as during cancer therapy, Understanding p53’s role in developmental diseases such as CHARGE syndrome, Characterizing p53-regulated noncoding RNAs and their roles in cancer, Examining mechanisms of p53 gain-of-function properties in cancer
Bieging-Rolett K T, Johnson T M, Brady C A, Beaudry V G, Pathak N, et al. (2016) p19(Arf) is required for the cellular response to chronic DNA damage. Oncogene 35(33): 4414-4421.