Tushar Desai
Assistant Professor
Medicine - Pulmonary & Critical Care Medicine
Stanford University School of Medicine
United States of America
Biography
Dr. Tushar Desai specializes in the treatment of general pulmonary and Interstitial Lung Diseases like Idiopathic Pulmonary Fibrosis (IPF). He has practiced pulmonary medicine since 2002. Dr. Desai has a special interest in understanding the development and progression of diseases like IPF, Chronic Obstructive Pulmonary Disease (COPD), and lung adenocarcinoma, as well as in understanding how native lung stem cells function to repair the lung gas exchange surface after injury.
Research Interest
He and his team attempt to deeply characterize the normal biology of the lung, in vivo and at single cell resolution, using powerful and precise genetic and genomic tools. They then apply our fundamental understanding of lung biology to investigate which specific processes have gone awry in particular lung diseases, using a combination of experimental models and analysis of primary human disease samples. Their belief is that dissecting the specific mechanisms of disease pathogenesis will enable the rational design of highly targeted therapies that have the potential to halt disease without conferring significant off-target toxicities.
Publications
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Desai TJ, Brownfield DG, Krasnow MA (2014) Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature 507: 190-194
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Treutlein B, Brownfield DG, Wu AR, Neff NF, Mantalas GL, et al. (2014) Reconstructing lineage hierarchies of the distal lung epithelium using single-cell RNA-seq. Nature 509: 371-375
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Logan CY, Desai TJ (2015) Keeping it together: Pulmonary alveoli are maintained by a hierarchy of cellular programs. BioEssays 37: 1028-1037