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Ami Bhatt

Assistant Professor
Medicine
Stanford University
United States of America

Biography

In perpetual awe of how 'simple' microbial organisms can perturb complex, multicellular eukaryotic organisms, Ami Bhatt has chosen to dedicate her research program to inspecting, characterizing and dissecting the microbe-human interface. Nowhere is the interaction between hosts and microbes more potentially impactful than in immunocompromised hosts and global settings where infectious and environmental exposures result in drastic and sometimes fatal health consequences. Ami's group identifies problems and questions that arise in the course of routine clinical care. Often in collaboration with excellent investigators at Stanford and beyond, the group applies modern genetic, molecular and computational techniques to seek answers to these questions, better understand host-microbe interactions and decipher how perturbation of these interactions may result in human disease phenotypes.

Research Interest

a. To catalog, more completely, the components of the human microbiome in states of health and disease using high-thorughput and relatively unbiased methods such as shotgun DNA sequencing. b. To understand if shifts in the microbiome are associated with human disease phenotypes. c. If alterations in the microbiome are associated with human disease phenotypes, identify and target microbial vulnerabilities with the hope of ameliorating these disease phenotypes.

Publications

  • Bhatt AS, Welm A, Farady CJ, Vasquez M, Wilson K, Craik CS (2007) Coordinate expression and functional profiling identify an extracellular proteolytic signaling pathway PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 104: 5771-5776

  • Ng S, Fanta C, Okam M, Bhatt AS (2011) NK-Cell and B-Cell Deficiency with a Thymic Mass NEW ENGLAND JOURNAL OF MEDICINE 364: 586-588

  • VE, Bhatt AS (2015) The human microbiome in hematopoiesis and hematologic disorders. Blood Manzo 126: 311-318

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