David N. Cornfield
United States of America
Our lab addresses the regulation of pulmonary vascular tone. We investigate the signal transduction pathway of molecules that play an important role in determining pulmonary vascular tone. We identified a novel role for HIF-1α in the regulation of tone in lung via effects on myosin light chain phosphorylation in the pulmonary artery smooth muscle cells and in regulating expression of the β1 subunit of the calcium sensitive potassium channel. We outlined a novel role for endothelin derived from smooth muscle cells in modulating the pulmonary vascular response to hypoxia. Most recently, we have undertaken a line of research using human tissue.
Pediatric Pulmonary Med, Pediatric Critical Care Medicine, Pediatric Pulmonary.