James Spudich
Professor
Biochemistry
Stanford University
United States of America
Biography
James Spudich Professor of Cardiovascular Disease, is in the Department of Biochemistry at Stanford University School of Medicine. He received his B.S. in chemistry from the University of Illinois in 1963 and his Ph.D. in biochemistry from Stanford in 1968. He did postdoctoral work in genetics at Stanford and in structural biology at the MRC Laboratory in Cambridge, England. From 1971 to 1977 he was Assistant, Associate, and Full Professor in the Department of Biochemistry and Biophysics, University of California, San Francisco.
Research Interest
molecular basis of cell motility
Publications
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KI Mortensen, J Sung, H Flyvbjerg, JA Spudich (2015) Optimized measurements of separations and angles between intra-molecular fluorescent markers Nat Commun 6:8621.
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EM Green, H Wakimoto, RL Anderson, MJ Evanchik, JM Gorham (2016) A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice Science 351:617-21
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Julian R. Homburger, Eric M. Green, Colleen Caleshu, Margaret S. Sunitha (2016) Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation Proc Natl Acad Sci U S A 113(24): 6701–6706.
