Jeffrey S. Glenn
Associate Professor
Microbiology & Immunology
Stanford University
United States of America
Biography
Jeffrey S. Glenn is working as Associate Professor, Medicine - Gastroenterology & Hepatology, Microbiology & Immunology. Member of Bio-X, Child Health Research Institute. Faculty Fellow of Stanford ChEM-H.
Research Interest
Dr. Glenn's primary interest is in molecular virology, with a strong emphasis on translating this knowledge into novel antiviral therapies. Current projects aim to better understand the role of prenylation in the life cycles of hepatitis delta virus (HDV) and other viruses-both as a mechanism of intracellular trafficking and trigger of virus assembly, and as a target for a promising antiviral treatment. The function and cell biology of the hepatitis C virus (HCV) non-structural proteins are also being studied. Here the focus is on identifying key determinants of pathogenesis and designing novel antiviral strategies. Other interests include exploitation of hepatic stem cells, development of a small animal model for HCV, and engineered human liver tissues.
Publications
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Pang PS, Pham EA, Elazar M, Patel SG, Glenn JS et al. (2012) Structural Map of a MicroRNA-122: Hepatitis C Virus Complex. JOURNAL OF VIROLOGY 86: 1250-1254.
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Lisowski L, Elazar M, Chu K, Glenn JS, Kay MA (2013) The anti-genomic (negative) strand of Hepatitis C Virus is not targetable by shRNA. Nucleic acids research 41: 3688-3698.
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David N, Yaffe Y, Hagoel L, Elazar M, Glenn JS, et al (2015) The interaction between the Hepatitis C proteins NS4B and NS5A is involved in viral replication. Virology 475: 139-149.
