Jerome Murphy

Biography

The Bejerano Lab studies genome function in human and related species. We are deeply interested in the following broad questions: Mapping genome sequence (variation) to phenotype (differences) and extracting specific genetic insights from deep sequencing measurements. We take a particular interest in gene cis regulation. We use our joint affiliation to apply a combination of computational and experimental approaches. We collect large scale experimental data; write computational analysis tools; run them massively to discover the most exciting testable hypotheses; which we proceed to experimentally validate. We work in small teams, in house or with close collaborators of experimentalists and computational tool users who interact directly with our computational tool builders. Please see our research tab for more.

Research Interest

Genotype - Phenotype relationships in humans. We are developing novel methods for linking human whole genome variation with human disease and trait variation. We apply these methods to multiple datasets in the contexts of prematurity, autism, heart disease and more [20, 29, 32, 34, 36, 38, 39, 43]. 2. Genotype - Phenotype relationships between mammals. We develop novel methods to link trait evolution in the mammalian tree to whole genome evolution in over a hundred species. Application of these methods allow us to shed new light on human genome function, on human disease and on human evolution [29, 34, 35]. See our "Forward Genomics" web server.