Sundari Chetty
Instructor
Psychiatry and Behavioral Sciences
Stanford University
United States of America
Biography
Dr.Sundari Chetty lab is interested in understanding the mechanisms regulating human pluripotent stem cell (hPSC) differentiation. Pluripotent stem cells have great therapeutic potential because they can in theory differentiate into any specialized cell type of the body. However, unlocking this vast potential of stem cells has proven to be challenging in practice. The overarching goal of our research program is to understand these mechanisms to more effectively differentiate hPSCs into desired cell types for cell replacement therapy and disease modeling.
Research Interest
Current projects focus on understanding the genetic and epigenetic mechanisms controlling the developmental potential of hPSCs. We are particularly interested in applying this knowledge to improve the differentiation potential of hPSCs into neuronal and glial cells for understanding the pathology and treatment of neuropsychiatric disorders.
Publications
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Chetty S, Friedman AR, Taravosh-Lahn K, Kirby ED, Mirescu C, et al. (2014) Stress and glucocorticoids promote oligodendrogenesis in the adult hippocampus. Molecular Psychiatry 19: 1275-1283
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Chetty S, Engquist EN, Mehanna E, Lui KO, Tsankov AM, et al. (2015) A Src inhibitor regulates the cell cycle of human pluripotent stem cells and improves directed differentiation. J cellbiology 210: 1257-1268
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Tsankov AM, Akopian V, Pop R, Chetty S, Gifford CA, et al. (2015)A qPCRCR ScoreCard quantifies the differentiation potential of human pluripotent stem cells. Nature Biotechnology 33: 1182-U117
