Microbiology & Immunology
United States of America
She is working as Associate Professor, Medicine - Infectious Diseases, Microbiology & Immunology. Member of Bio-X, Child Health Research Institute. Division Chief, Infectious Diseases and Geographic Medicine.
Dr Singh studies the molecular basis of pathogenesis of a medically important parasite, Entamoeba histolytica. The work is aimed at understanding the virulence determinants that E. histolytica utilizes in causing invasive colonic and hepatic disease. Using a combination of genetic and genomic approaches we are identifying novel mechanisms that the parasite has developed for invading the human host. Additionally, we study the epidemiological trends of of amebic infection, with the goal of identifying a parasite molecular signature that correlates with invasive potential.
Foda BM, Singh U (2015) Dimethylated H3K27 Is a Repressive Epigenetic Histone Mark in the Protist Entamoeba histolytica and Is Significantly Enriched in Genes Silenced via the RNAi Pathway. JOURNAL OF BIOLOGICAL CHEMISTRY 290: 21114-21130.
Khalil MI, Foda BM, Suresh S, Singh U (2016) Technical advances in trigger-induced RNA interference gene silencing in the parasite Entamoeba histolytica INTERNATIONAL JOURNAL FOR PARASITOLOGY 46: 205-212
Suresh S, Ehrenkaufer G, Zhang H, Singh U (2016) Development of RNA Interference Trigger-Mediated Gene Silencing in Entamoeba invadens. Infection and immunity 84: 964-975.