Stony Brook University
United States of America
Christian Sheline, PhD is a Research Associate Professor in the Department of Neurology and Neurosciences Institute Administrator in the Stony Brook University
Establish the role of Zn2+ toxicity in many injuries and disease states, The efficacy of Zn2+ therapeutics (pyruvate, nicotinamide, sirtuin inhibition, a reduced zinc diet, or knockout of zinc transporters) as quantified by systematic counting of neurons in animal models of Huntington’s and Parkinson’s diseases, global ischemia, light-induced retinal damage, hypoglycemia, diabetes, and trophic deprivation.
Sheline C. T., Behrens M. M., Choi D. W. (2000) Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD(+) and inhibition of glycolysis. Journal of Neuroscience 20(9): 3139-46; PMID: 10777777.
Okamoto, H., Sheline, C.T., Corden, J.L., Jones, K.A., Peterlin, B.M. (1996) Trans-activation by human immunodeficiency virus tat protein requires the c-terminal domain of RNA polymerase II. PNAS 93(21):11575-9; PMID: 8876177.
Melendy, T., Sheline, C. T., Ray, D.S. (1988) Localization of a type II DNA topoisomerase to two sites at the periphery of the kinetoplast DNA of Crithidia fasciculata. Cell 55, 1083-1088; PMID: 2849507.