Dale G. Deutsch
Biochemistry and Cell Biology
Stony Brook University
United States of America
Dale G. Deutsch joined as Professor of Department of Biochemistry and Cell Biology,The Stony Brook University School of Medicine.
Nearly all neurotransmitters are water soluble and, as such, require a transmembrane protein transporter to pass through the lipid membrane for inactivation inside the cell. However, using model systems, we and others have shown that this is unnecessary for anandamide, an uncharged hydrophobic molecule that readily diffuses across the cellular membrane. Interestingly, its uptake is driven by the concentration gradient resulting from its breakdown mainly by FAAH localized in the endoplasmic reticulum.