Biochemistry and Cell Biology
Stony Brook University
United States of America
Wali Karzai joined as Professor of Department of Biochemistry and Cell Biology,The Stony Brook University School of Medicine.
Post-transcriptional Regulation of Gene Expression Post-transcriptional processing events play a crucial role in controlling gene expression. Our research is aimed at elucidating post-transcriptional gene regulatory processes in prokaryotes. We are particularly interested in investigating: 1) Molecular mechanisms that govern translation quality control; 2) Molecular basis for nonstop mRNA decay; 3) The mechanisms by which RNases and small non-coding RNAs (ncRNAs) regulate gene expression and RNA stability; 4) Biochemical mechanism of targeted proteolysis and the role of AAA+ proteases in bacterial pathogenesis; 5) Discovery of novel antibiotics and vaccines. Our Approach We use a combination of protein biochemistry, molecular genetics, functional genomics, bioinformatics, and structural approaches to determine the biological function and mechanism of action of RNA-protein complexes that participate in regulation of gene expression.