Wali Karzai
Associate Professor
Biochemistry and Cell Biology
Stony Brook University
United States of America
Biography
Wali Karzai joined as Professor of Department of Biochemistry and Cell Biology,The Stony Brook University School of Medicine.
Research Interest
Post-transcriptional Regulation of Gene Expression Post-transcriptional processing events play a crucial role in controlling gene expression. Our research is aimed at elucidating post-transcriptional gene regulatory processes in prokaryotes. We are particularly interested in investigating: 1) Molecular mechanisms that govern translation quality control; 2) Molecular basis for nonstop mRNA decay; 3) The mechanisms by which RNases and small non-coding RNAs (ncRNAs) regulate gene expression and RNA stability; 4) Biochemical mechanism of targeted proteolysis and the role of AAA+ proteases in bacterial pathogenesis; 5) Discovery of novel antibiotics and vaccines. Our Approach We use a combination of protein biochemistry, molecular genetics, functional genomics, bioinformatics, and structural approaches to determine the biological function and mechanism of action of RNA-protein complexes that participate in regulation of gene expression.
