Katherine L. Perkins
Associate Professor
Physiology and Pharmacology Department
Suny Downstate Medical Center
United States of America
Biography
Katherine L. Perkins is Associate Professor in the department of Physiology and Pharmacology at SUNY Downstate Medical Center, United States of America.
Research Interest
GABA, which is released from interneurons, is the main inhibitory neurotransmitter in the brain. However, under certain circumstances, GABA depolarizes and excites the postsynaptic pyramidal cell and can actually trigger epileptiform activity. In addition, certain interneurons in the hippocampus are excited by exogenously applied GABA and by GABA released from other interneurons. We are studying these interneuron networks and the role they play in the epileptiform activity that occurs in the hippocampus and entorhinal cortex.
Publications
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Perkins KL (2006) Cell-attached voltage-clamp and current-clamp recording and stimulation techniques in brain slices. J Neurosci Meth 154: 1-18.
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Perkins KL (2002) GABA application to hippocampal CA3 or CA1 stratum lacunosum-moleculare excites an interneuron network. J Neurophysiol 87: 1404-1414.
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Perkins KL, Wong RKS (1996) Ionic basis of the postsynaptic depolarizing GABA response in hippocampal pyramidal cells. J Neurophysiol 76: 3886-3894.
