James Hougland
Associate Professor
Chemistry
Syracuse University
United States of America
Biography
James Hougland is an Associate Professor in the Department of Chemistry at Syracuse University, New York, United States. He has interests in enzymes that recognize their substrates and catalyze reactions and the impact of the resulting modification(s) on protein function within the cell.
Research Interest
Bioorganic chemistry, Biochemistry, Enzymology, Post-translational modification, Molecular biology.
Publications
-
Gangopadhyay SA, Losito EL, Hougland JL (2014) Targeted reengineering of protein geranylgeranyltransferase type I selectivity functionally implicates active-site residues in protein-substrate recognition. Biochemistry 53: 434-446.
-
Flynn SC, Lindgren DE, Hougland JL (2014) Quantitative Determination of Cellular Farnesyltransferase Activity: Towards Defining the Minimum Substrate Reactivity for Biologically Relevant Protein Farnesylation. ChemBioChem 15: 2205-2210.
-
Darling JE, Zhao F, Loftus RJ, Patton LM, Gibbs RA, et al. (2015) Structure–activity analysis of human ghrelin O-acyltransferase reveals chemical determinants of ghrelin selectivity and acyl group recognition. Biochemistry 54: 1100-1110.
