Nahum Duker

Biography

Nahum Duker is a Professor of Pathology and Laboratory Medicine Assistant Professor, Fels Institute for Cancer Research and Molecular Biology at Temple University.

Research Interest

A paradigm for etiogenesis of neurodegenerative disorders has emerged which implicates unrepaired oxidative DNA damage in neuron cell death via apoptosis. Evidence indicates unrepaired DNA purine dimers to be the molecular link between intracerebral deposition of amyloid-ß protein [Aß] and neural cell loss in Alzheimer's disease. Aß reacts with the receptor for advanced glycation end products [RAGE], resulting in generation of free radicals; these result in oxidative DNA damages.