Sarah Lebeis
Assistant Professor
Department of Microbiology
Tennessee State University
United States of America
Biography
Dr.Sarah Lebeis has completed her PhD in 2008 from Emory University and presently working as Assistant Professor at University of Tennessee.
Research Interest
The research performed in this laboratory brings together microbiology, immunology, and metagenomics to further understand microbial communities associated with plants. Microbes found in roots perform a variety of functions for their host, including: nutrient acquisition, growth promotion, and disease prevention. We will determine how the immune system in the model plant, Arabidopsis thaliana acts to exclude microbes from joining communities found in root systems. Although a wide diversity of microbes are present in the soil, only limited microbial taxa can colonize inside of the root tissue, indicating that microbes found in the root tissue must pass through several levels of selection. Together, these studies will partially dissect the complex relationship that exists between hosts and their microbial communities and extend our understanding of host immune systems.
Publications
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Lebeis SL, Paredes SH, Lundberg DS, Breakfield N, Gehring J, McDonald M, Malfatti S, Del Rio TG, Jones CD, Tringe SG, Dangl JL. Salicylic acid modulates colonization of the root microbiome by specific bacterial taxa. Science. 2015 Aug 21;349(6250):860-4.
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Lebeis SL, Bommarius B, Parkos CA, Sherman MA, Kalman D. TLR signaling mediated by MyD88 is required for a protective innate immune response by neutrophils to Citrobacter rodentium. The Journal of Immunology. 2007 Jul 1;179(1):566-77.
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Reeves PM, Bommarius B, Lebeis S, McNulty S, Christensen J, Swimm A, Chahroudi A, Chavan R, Feinberg MB, Veach D, Bornmann W. Disabling poxvirus pathogenesis by inhibition of Abl-family tyrosine kinases. Nature medicine. 2005 Jul 1;11(7):731.
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Lundberg DS, Lebeis SL, Paredes SH, Yourstone S, Gehring J, Malfatti S, Tremblay J, Engelbrektson A, Kunin V, Del Rio TG, Edgar RC. Defining the core Arabidopsis thaliana root microbiome. Nature. 2012 Aug 2;488(7409):86.
