David Peterson
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
A.B. Pomona College (1972) Ph.D. Harvard University (1978) Postdoc. University of California, San Francisco (1978-81) Joined Texas A&M in 1981
Research Interest
David is interested in the molecular mechanisms of transcriptional regulation in mammalian cells. Many of our experiments have focused on the transcription of the proviral genome of the retrovirus mouse mammary tumor virus, which is subject to both positive and negative control. A number of cellular proteins that are important for viral transcription have been identified, and we would like to define the precise roles of these proteins in establishing correct levels of viral gene expression. We are also exploring some specific questions related to the general mechanism of transcription initiation by RNA polymerase II and the biochemical details of transcriptional regulation
Publications
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Chen, X, Zhang, B, Harmon, PM, Schaffner, W, Peterson, DO, Giedroc, DP et al.. A novel cysteine cluster in human metal-responsive transcription factor 1 is required for heavy metal-induced transcriptional activation in vivo. J. Biol. Chem. 2004;279 (6):4515-22. doi: 10.1074/jbc.M308924200. PubMed PMID:14610091. .
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Knippa, K, Peterson, DO. Fidelity of RNA polymerase II transcription: Role of Rpb9 [corrected] in error detection and proofreading. Biochemistry. 2013;52 (44):7807-17. doi: 10.1021/bi4009566. PubMed PMID:24099331. .
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Kaster, BC, Knippa, KC, Kaplan, CD, Peterson, DO. RNA Polymerase II Trigger Loop Mobility: INDIRECT EFFECTS OF Rpb9. J. Biol. Chem. 2016;291 (28):14883-95. doi: 10.1074/jbc.M116.714394. PubMed PMID:27226557. PubMed Central PMC4938204.
