Hays Rye
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
A fundamental principle of biology is the use of chemical energy in the form of ATP to assemble, disassemble and alter macromolecular structure. Specialized control proteins known as molecular chaperones are often responsible for this activity and have been recognized in recent years to be essential for regulating many aspects of cellular biology
Research Interest
(1) protein folding (2) protein disaggregation and (3) vesicle trafficking. In each of these cases, large quantities ATP are burned, resulting in molecular organization in the case of protein folding, and molecular disassembly and remodeling in the case of protein disaggregation and vesicle trafficking
Publications
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Weaver, J, Watts, T, Li, P, Rye, HS. Structural basis of substrate selectivity of E. coli prolidase. PLoS ONE. 2014;9 (10):e111531. doi: 10.1371/journal.pone.0111531. PubMed PMID:25354344. PubMed Central PMC4213023.
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Brooks, A, Shoup, D, Kustigian, L, Puchalla, J, Carr, CM, Rye, HS et al.. Single particle fluorescence burst analysis of epsin induced membrane fission. PLoS ONE. 2015;10 (3):e0119563. doi: 10.1371/journal.pone.0119563. PubMed PMID:25799353. PubMed Central PMC4370887.
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Weaver, J, Jiang, M, Roth, A, Puchalla, J, Zhang, J, Rye, HS et al.. GroEL actively stimulates folding of the endogenous substrate protein PepQ. Nat Commun. 2017;8 :15934. doi: 10.1038/ncomms15934. PubMed PMID:28665408. PubMed Central PMC5497066
