James Sacchettini
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
Ph.D. Washington University, St. Louis (1987) Postdoc. Washington University, St. Louis (1987-89) Professor. Albert Einstein College of Medicine Joined Texas A&M in 1996
Research Interest
My lab uses X-ray crystallography to better understand the relationship between proteins and ligands. Tiny differences in the structure of a molecule can radically change the interaction between a protein and ligand and we are only begining to understand how many factors play a role in this interaction
Publications
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Patel, N, O'Malley, T, Zhang, YK, Xia, Y, Sunde, B, Flint, L et al.. A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro. Antimicrob. Agents Chemother. 2017;61 (9):. doi: 10.1128/AAC.01205-17. PubMed PMID:28674058. PubMed Central PMC5571309.
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Pham, TV, Murkin, AS, Moynihan, MM, Harris, L, Tyler, PC, Shetty, N et al.. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (29):7617-7622. doi: 10.1073/pnas.1706134114. PubMed PMID:28679637. PubMed Central PMC5530696.
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Thapa, HR, Tang, S, Sacchettini, JC, Devarenne, TP. Tetraterpene Synthase Substrate and Product Specificity in the Green Microalga Botryococcus braunii Race L. ACS Chem. Biol. 2017;12 (9):2408-2416. doi: 10.1021/acschembio.7b00457. PubMed PMID:28813599. .
