Jean-philippe Pellois
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
M.Sc. Ecole Supérieure de Chimie Physique Electronique de Lyon (1999) Ph.D. University of Houston (2002) Postdoc. The Rockefeller University (2002-2006) Joined Texas A&M in 2006
Research Interest
Our goal is to determine how proteins function in space and time in the context of complex cellular networks. We focus on chemistry-driven approaches to manipulate protein structure beyond what is feasible with standard genetics. In particular, we use semi-synthetic light-activatable proteins as biophysical probes to investigate protein mechanisms inside living cells. Areas of interest include the important but poorly understood process of protein S-acylation, signal transduction, and protein trafficking.
Publications
-
Najjar, K, Erazo-Oliveras, A, Brock, DJ, Wang, TY, Pellois, JP. An l- to d-Amino Acid Conversion in an Endosomolytic Analog of the Cell-penetrating Peptide TAT Influences Proteolytic Stability, Endocytic Uptake, and Endosomal Escape. J. Biol. Chem. 2017;292 (3):847-861. doi: 10.1074/jbc.M116.759837. PubMed PMID:27923812. PubMed Central PMC5247658.
-
Wang, TY, Libardo, MDJ, Angeles-Boza, AM, Pellois, JP. Membrane Oxidation in Cell Delivery and Cell Killing Applications. ACS Chem. Biol. 2017;12 (5):1170-1182. doi: 10.1021/acschembio.7b00237. PubMed PMID:28355059. .
-
Libardo, MDJ, Wang, TY, Pellois, JP, Angeles-Boza, AM. How Does Membrane Oxidation Affect Cell Delivery and Cell Killing? Trends Biotechnol. 2017;35 (8):686-690. doi: 10.1016/j.tibtech.2017.03.015. PubMed PMID:28460718. PubMed Central PMC5522782.
