Jorge Cruz-reyes
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
Jorge Cruz-Reyes combine and approaches in molecular genetics, structural biology, biochemistry, proteomics, and bioinformatics to study the amazing RNA biology of trypanosome parasites. One research line is on an RNA editing process by uridine insertion and deletion that creates amino acid coding triplets in most mRNAs. Yet a single error in the U-changes yields a frame-shift. Trypanosomes split from other eukaryotic lineages over 100 Ma, yet this editing has analogies with RNAi, CRISPR/Cas9, mRNA splicing and other systems directed by small non-coding RNAs (ncRNAs).
Research Interest
Biochemistry and Biophysics
Publications
-
Madina, BR, Kumar, V, Mooers, BH, Cruz-Reyes, J. Native Variants of the MRB1 Complex Exhibit Specialized Functions in Kinetoplastid RNA Editing. PLoS ONE. 2015;10 (4):e0123441. doi: 10.1371/journal.pone.0123441. PubMed PMID:25928631. PubMed Central PMC4415780.
-
Kumar, V, Madina, BR, Gulati, S, Vashisht, AA, Kanyumbu, C, Pieters, B et al.. REH2C Helicase and GRBC Subcomplexes May Base Pair through mRNA and Small Guide RNA in Kinetoplastid Editosomes. J. Biol. Chem. 2016;291 (11):5753-64. doi: 10.1074/jbc.M115.708164. PubMed PMID:26769962. PubMed Central PMC4786712.
-
Cruz-Reyes, J, Mooers, BH, Abu-Adas, Z, Kumar, V, Gulati, S. DEAH-RHA helicase•Znf cofactor systems in kinetoplastid RNA editing and evolutionarily distant RNA processes. RNA Dis. ;3 (2):. doi: 10.14800/rd.1336. PubMed PMID:27540585. PubMed Central PMC4987287.
