Magnus Höök
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
B.S. University of Uppsala, Sweden (1971),Ph.D. University of Uppsala, Sweden (1974)
Research Interest
The primary interest of our laboratory is to try to understand the structural function of the extracellular matrix. Of particular interest is the study of the molecular mechanisms of microbial adhesion to host tissue. This process, which is believed to represent a critical initial step in the development of infections, involves specific cell-surface proteins that recognize and bind with a high affinity to components in the host tissue. Our goal is to decipher these events at a molecular level and, based on structural analysis of the interacting components, design new strategies to prevent and treat infections.
Publications
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Ganesh, VK, Liang, X, Geoghegan, JA, Cohen, AL, Venugopalan, N, Foster, TJ et al.. Lessons from the Crystal Structure of the S. aureus Surface Protein Clumping Factor A in Complex With Tefibazumab, an Inhibiting Monoclonal Antibody. EBioMedicine. 2016;13 :328-338. doi: 10.1016/j.ebiom.2016.09.027. PubMed PMID:27789272. PubMed Central PMC5264652.
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Munoz-Pinto, DJ, Erndt-Marino, JD, Becerra-Bayona, SM, Guiza-Arguello, VR, Samavedi, S, Malmut, S et al.. Evaluation of late outgrowth endothelial progenitor cell and umbilical vein endothelial cell responses to thromboresistant collagen-mimetic hydrogels. J Biomed Mater Res A. 2017;105 (6):1712-1724. doi: 10.1002/jbm.a.36045. PubMed PMID:28218444. .
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Casillas-Ituarte, NN, Cruz, CHB, Lins, RD, DiBartola, AC, Howard, J, Liang, X et al.. Amino acid polymorphisms in the fibronectin-binding repeats of fibronectin-binding protein A affect bond strength and fibronectin conformation. J. Biol. Chem. 2017;292 (21):8797-8810. doi: 10.1074/jbc.M117.786012. PubMed PMID:28400484. PubMed Central PMC5448106.
