Pingwei Li
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
Ph.D. Peking University (1996) Postdoc. Fred Hutchinson Cancer Research Center (1998-2001) Postdoc. California Institute of Technology (2003-2005) Joined Texas A&M in 2005
Research Interest
Our comprehensive structural and functional studies provided critical insights into the mechanisms of DNA sensing through the cGAS/STING pathway. However, the detailed mechanisms of how cytosolic DNA mediates the induction of IFNs are still not fully understood. For example, it is not clear how cGAMP binding by STING initiates the signaling cascade
Publications
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Shen, Q, Zeng, D, Zhao, B, Bhatt, VS, Li, P, Cho, JH et al.. The Molecular Mechanisms Underlying the Hijack of Host Proteins by the 1918 Spanish Influenza Virus. ACS Chem. Biol. 2017;12 (5):1199-1203. doi: 10.1021/acschembio.7b00168. PubMed PMID:28368102. .
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Zhang, Z, Hu, F, Sung, MW, Shu, C, Castillo-González, C, Koiwa, H et al.. RISC-interacting clearing 3'- 5' exoribonucleases (RICEs) degrade uridylated cleavage fragments to maintain functional RISC in Arabidopsis thaliana. Elife. 2017;6 :. doi: 10.7554/eLife.24466. PubMed PMID:28463111. PubMed Central PMC5451212.
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Guo, X, Shu, C, Li, H, Pei, Y, Woo, SL, Zheng, J et al.. Cyclic GMP-AMP Ameliorates Diet-induced Metabolic Dysregulation and Regulates Proinflammatory Responses Distinctly from STING Activation. Sci Rep. 2017;7 (1):6355. doi: 10.1038/s41598-017-05884-y. PubMed PMID:28743914. PubMed Central PMC5526935.
