Steven Safe
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
D.Phil. Oxford University (1966) Postdoc. Oxford and Harvard Universities (1966-68) Joined Texas A&M in 1981
Research Interest
Research on estrogen-dependent gene expression in various cancer cell lines is focused on analysis of several gene promoters to determine the mechanisms of ERa and ERb action. This includes several genes that are activated through interactions of the ER with Sp1 protein and other DNA-bound transcription factors
Publications
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Phillips, TD, Richardson, M, Cheng, YS, He, L, McDonald, TJ, Cizmas, LH et al.. Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures. Arch. Toxicol. 2015;89 (6):967-77. doi: 10.1007/s00204-014-1285-8. PubMed PMID:24888377. PubMed Central PMC4254891
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Goldberg, AA, Draz, H, Montes-Grajales, D, Olivero-Verbél, J, Safe, SH, Sanderson, JT et al.. 3,3'-Diindolylmethane (DIM) and its ring-substituted halogenated analogs (ring-DIMs) induce differential mechanisms of survival and death in androgen-dependent and -independent prostate cancer cells. Genes Cancer. 2015;6 (5-6):265-280. . PubMed PMID:26124925. PubMed Central PMC4482247.
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Godugu, C, Doddapaneni, R, Safe, SH, Singh, M. Novel diindolylmethane derivatives based NLC formulations to improve the oral bioavailability and anticancer effects in triple negative breast cancer. Eur J Pharm Biopharm. 2016;108 :168-179. doi: 10.1016/j.ejpb.2016.08.006. PubMed PMID:27586082. .
