Tatyana Igumenova
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
Aberrant levels of PKC expression or activity have been implicated in a large number of human diseases, such as cancer, cardiac failure, Alzheimer’s disease, and diabetes. Despite the significance of PKC in signal transduction and human health, the structural and dynamical basis of its activation upon binding to lipid membranes remains elusive
Research Interest
broadly interested in understanding the structural basis of signal transduction events that occur at the membrane surface. These events are mediated by signaling proteins that reversibly associate with membranes in response to binding second messengers, such as Ca2+ ions, diacylglycerol, and phosphoinositides
Publications
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Morales, KA, Yang, Y, Cole, TR, Igumenova, TI. Dynamic Response of the C2 Domain of Protein Kinase Cα to Ca(2+) Binding. Biophys. J. 2016;111 (8):1655-1667. doi: 10.1016/j.bpj.2016.09.008. PubMed PMID:27760353. PubMed Central PMC5071625.
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Stewart, MD, Igumenova, TI. Toggling of Diacylglycerol Affinity Correlates with Conformational Plasticity in C1 Domains. Biochemistry. 2017;56 (21):2637-2640. doi: 10.1021/acs.biochem.7b00228. PubMed PMID:28505428. PubMed Central PMC5600822.
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Katti, S, Nyenhuis, SB, Her, B, Srivastava, AK, Taylor, AB, Hart, PJ et al.. Non-Native Metal Ion Reveals the Role of Electrostatics in Synaptotagmin 1-Membrane Interactions. Biochemistry. 2017;56 (25):3283-3295. doi: 10.1021/acs.biochem.7b00188. PubMed PMID:28574251. PubMed Central PMC5600830.
