Vytas Bankaitis
professor
Biochemistry and Biophysics
Texas A and M University
United States of America
Biography
Vytas is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions. The focus of our work is the phosphatidylinositol/ phosphatidylcholine transfer proteins (PITPs), a ubiquitous but enigmatic class of proteins. Ongoing projects in the laboratory derive from a multidisciplinary approach that encompasses biochemical characterization of novel members of the metazoan PITP family, and the application of genetic, molecular and biophysical approaches to detailed structural and functional analyses of PITPs. The laboratory breaks down into two groups: a group that studies the mechanism of function of yeast PITPs, and a group that generates knockout mice and analyzes the function of specific PITP isoforms in the mammal
Research Interest
My laboratory is interested in the regulatory interfaces between novel lipid-mediated signal transduction pathways and important cellular functions
Publications
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Blank, HM, Perez, R, He, C, Maitra, N, Metz, R, Hill, J et al.. Translational control of lipogenic enzymes in the cell cycle of synchronous, growing yeast cells. EMBO J. 2017;36 (4):487-502. doi: 10.15252/embj.201695050. PubMed PMID:28057705. .
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Tribble, EK, Ivanova, PT, Grabon, A, Alb, JG Jr, Faenza, I, Cocco, L et al.. Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts. J. Lipid Res. 2016;57 (8):1492-506.
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Grabon, A, Orłowski, A, Tripathi, A, Vuorio, J, Javanainen, M, Róg, T et al.. Dynamics and energetics of the mammalian phosphatidylinositol transfer protein phospholipid exchange cycle. J. Biol. Chem. 2017;292 (35):14438-14455. doi: 10.1074/jbc.M117.791467. PubMed PMID:28718450. PubMed Central PMC5582838.
