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Molecular Biology Experts

E. Sally Ward, Phd

Professor
Department of Molecular and Cellular Medicine
Texas A&M University
United States of America

Biography

Dr. Sally Ward received her BA with First Class Honours in natural sciences (Part II course, biochemistry), University of Cambridge, U.K., in 1982 and completed her PhD in biochemistry at the Department of Biochemistry, University of Cambridge, under the mentorship of Professor David J. Ellar in 1985. From 1988 to 1990 she held the Stanley Elmore Senior Medical Research Fellow at Sidney Sussex College, Cambridge whilst working with Sir Greg Winter at the MRC Laboratory of Molecular Biology, Cambridge, U.K. She became an assistant professor in 1990 at the University of Texas Southwestern Medical Center in Dallas. Ward was promoted in 2002 to professor in the Department of Immunology at UT Southwestern and was appointed to the Paul and Betty Meek-FINA Professorship in Molecular Immunology in 2004. Ward joined the faculty at the Texas A&M University Health Science Center in September 2014.

Research Interest

The Ward laboratory is run jointly with the laboratory of Dr. Raimund Ober. The research is directed towards taking a highly interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mouse models of disease. These studies are funded by the National Institutes of Health, National Multiple Sclerosis Society, Cancer Prevention and Research Institute of Texas (CPRIT) and biopharma.

Publications

  • Garcia, K. C., Radu, C. G., Ho, J., Ober, R. J., and Ward, E. S. (2001) Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis, Proc. Natl. Acad. Sci. USA, 98, 6818-6823. PMID:11391002 http://www.ncbi.nlm.nih.gov/pubmed/11391002

  • Ghetie, V., Popov, S., Borvak, J., Radu, C., Matesoi, D., Medesan, C., Ober, R. J., and Ward, E. S. (1997) Increasing the serum persistence of an IgG fragment by random mutagenesis, Nat. Biotechnol., 15, 637-640. PMID: 9219265 http://www.ncbi.nlm.nih.gov/pubmed/9219265

  • Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y., and Ward, E. S. (1996) Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice, Eur. J. Immunol., 26, 690-696. PMID: 8605939 http://www.ncbi.nlm.nih.gov/pubmed/8605939

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